| PowerHouse PAX-1 (Pennsylvania Digital 1) | PowerHouse Data Centers | Carlisle | announced | 1350 MW |
| AWS Susquehanna / Cumulus Campus (Salem Township) | Amazon Web Services | Berwick | under construction | 960 MW |
| Edged Project Atlas Data Center | Edged Energy | Allentown | planned | 725 MW |
| Five 9s Digital Aliquippa Data Center | Five 9s Digital | Aliquippa | planned | 496 MW |
| Bitfarms Panther Creek | Bitfarms | Nesquehoning | under construction | 350 MW |
| Air Products Cetronia Road Data Center | Air Products | Upper Macungie Township | planned | 180 MW |
| Mawson Midland | Mawson Infrastructure Group | Midland | operating | 120 MW |
| Sharon Data Center | Bitfarms | Sharon | planned | 120 MW |
| Mawson Sharon | Mawson Infrastructure Group | Sharon | operating | 120 MW |
| Bitfarms Sharon | Bitfarms | Sharon | operating | 110 MW |
| CoreWeave Lancaster | CoreWeave | Lancaster | under construction | 100 MW |
| Chirisa Freeport data center (former BNY Mellon site) | Chirisa Technology Parks | Freeport | under construction | 100 MW |
| Lancaster Campus (CoreWeave) | Blue Owl/IPI | Lancaster | under construction | 100 MW |
| CoreWeave Lancaster Data Center | CoreWeave | Lancaster | planned | 100 MW |
| CoreWeave Lancaster AI data center | CoreWeave | Lancaster | under construction | 100 MW |
| Scrubgrass Data Center | Bitfarms | Kennerdell | operating | 85 MW |
| Stronghold Scrubgrass Plant | Stronghold Digital Mining | Kennerdell | operating | 83.5 MW |
| Panther Creek Data Center | Bitfarms | Nesquehoning | operating | 80 MW |
| SAP Newtown Square Enterprise Cloud Data Center | SAP America | Newtown Square | operating | 40 MW |
| Allentown - TekPark Data Center | TierPoint | Breinigsville | operating | 17 MW |
| Iron Mountain WPA-1 (Western Pennsylvania) | Iron Mountain Data Centers | Boyers | operating | 15.5 MW |
| Flexential Philadelphia - Collegeville Data Center | Flexential | Collegeville | operating | 7.2 MW |
| Expedient Pittsburgh Data Centers | Expedient | Pittsburgh | operating | 6 MW |
| DataBank PIT2 | DataBank | Pittsburgh | operating | 5 MW |
| Ardent Pittsburgh (McKees Rocks) | Northern Data | McKees Rocks | operating | 5 MW |
| Keystone NAP | Keystone NAP | Fairless Hills | operating | 2 MW |
| DataBank PIT1 | DataBank | Pittsburgh | operating | 1.9 MW |
| DataBank Pittsburgh PIT1 | DataBank | Pittsburgh | operating | 1.9 MW |
| Involta Pittsburgh | Involta | Pittsburgh | operating | 1.5 MW |
| DataBank PHL1 | DataBank | Philadelphia | operating | 0.34 MW |
| EdgeConneX Pittsburgh | EdgeConneX | Pittsburgh | operating | - |
| H5 Philadelphia | H5 Data Centers | Philadelphia | operating | - |
| 365 Data Centers Philadelphia (University City) | 365 Data Centers | Philadelphia | operating | - |
| International Electric Power Greene County data center campus | International Electric Power III, LLC | Greene County | announced | - |
| Nebius Highridge Business Park AI Factory | Nebius | Pottsville | announced | - |
| York 2 Energy Center Data Center | Energy Capital Partners / Calpine | Peach Bottom Township | announced | - |
| Fairview Crossroads Data Center | Elysian Partners LLC (Fairview Crossroads LLC) | Fairview Township | planned | - |
| Provident Pittsburgh International Race Complex Data Center | Provident Data Centers | Wampum | announced | - |
| Springdale (former Cheswick Generating Station) Data Center | Allegheny DC (Davidson Kempner) | Springdale | planned | - |
| Project Gravity Data Center Campus | Archbald 25 Developer LLC | Archbald | planned | - |
| Project Boson (Archbald Data & Energy Center) | PDC Realty | Archbald | planned | - |
| Slate Belt Holdings Data Center Campus | Slate Belt Holdings LLC (Talen Energy / River Pointe) | Upper Mount Bethel Township | planned | - |
| 4-3 Group Salem Township Data Center (second project) | 4-3 Glen Brook Group | Salem Township | announced | - |
| Colocation America Philadelphia (1000 Adams Ave, Eagleville) | ColocationAmerica | Eagleville | operating | - |
| Wampum (Pitt International Race Complex) Data Center | Provident Data Centers | Wampum | planned | - |
| Switch Big Beaver Data Center Campus | Switch | Big Beaver Borough | announced | - |
| Guardian Life Insurance Bethlehem Data Center | Guardian Life Insurance Company of America | Bethlehem | operating | - |
| Tarentum (Rockpointe) Data Center | Consolidated Communications | Tarentum | operating | - |
| AWS Kline Township Data Center Campus | Amazon Web Services | Kline Township | under construction | - |
| Prologis Lehigh Valley East 16 Data Center | Prologis | Bethlehem | under construction | - |
| AWS Lehigh Valley III Data Center | Amazon Web Services | Allentown | under construction | - |
| Constellation Energy Limerick Data Center | Constellation Energy | Limerick Township | planned | - |
| Keel Infrastructure Panther Creek Data Center | Keel Infrastructure | Nesquehoning | under construction | - |
| Vanguard Malvern Data Center | The Vanguard Group | Malvern | operating | - |
| Equinix PH1 | Equinix | Philadelphia | operating | - |
| American Tower Access Edge Pittsburgh | American Tower | Pittsburgh | operating | - |
| Lehigh Valley Data Center | TierPoint | Bethlehem | operating | - |
| Comcast National Data Center (East Goshen) | Comcast | East Goshen | operating | - |
| Penn Medicine Academic Computing Services HPC | University of Pennsylvania | Philadelphia | operating | - |
| Pennsylvania State Data Center | Pennsylvania Office of Administration | Middletown | operating | - |
| Pittsburgh Supercomputing Center (Bridges-2/Neocortex) | Pittsburgh Supercomputing Center | Pittsburgh | operating | - |
| Penn State Roar Supercomputer (ICDS) | Pennsylvania State University | University Park | operating | - |
| Windstream Hosted Solutions Ephrata Data Center | Windstream | Ephrata | operating | - |
| TierPoint Valley Forge Data Center | TierPoint | Valley Forge | operating | - |
| TierPoint Philadelphia Data Center | TierPoint | Philadelphia | operating | - |
| H5 Pittsburgh | H5 Data Centers | Pittsburgh | operating | - |
| Western Pennsylvania | Iron Mountain Data Centers | Boyers | operating | - |
| Scrubgrass Plant | Stronghold Digital Mining, Inc. | Scrubgrass Township | operating | - |
| Panther Creek Plant | Stronghold Digital Mining, Inc. | Nesquehoning | operating | - |
| Salem Township | QTS Data Centers | Salem Township | operating | - |
| PHL1 | Hivelocity | Philadelphia | operating | - |
| 401 North Broad | Netrality Data Centers | Philadelphia | operating | - |
| Netrality 401 North Broad | Netrality Data Centers | Philadelphia | operating | - |
| Valley Forge Data Center | TierPoint | Norristown | operating | - |
| Bethlehem Data Center | TierPoint | Bethlehem | operating | - |
| Colocation America Philadelphia (9999 Hamilton Blvd, Breinigsville) | ColocationAmerica | Breinigsville | operating | - |
| Pittsburgh Supercomputing Center (Bridges-2) | Pittsburgh Supercomputing Center | Monroeville | operating | - |
| Chirisa Technology Park Pittsburgh | Chirisa Technology Parks (CIM Group) | Pittsburgh | operating | - |
| Defense Enterprise Computing Center Mechanicsburg | Defense Information Systems Agency | Mechanicsburg | operating | - |
| AWS Falls Township / Keystone Trade Center Campus | Amazon Web Services | Falls Township | planned | - |
| Pittsburgh Supercomputing Center | Carnegie Mellon University and University of Pittsburgh | Pittsburgh | operating | - |
| LightWave Networks Philadelphia | LightWave Networks | Philadelphia | operating | - |
| Homer City Energy Campus | Homer City Redevelopment | Homer City | under construction | - |
| Pennsylvania DC, Phase 1 | Prudential Financial | Dresher | operating | - |
| Pittsburgh Data Center | Consolidated Communications | Pittsburgh | operating | - |
| 365 Data Centers Philadelphia (Downtown) | 365 Data Centers | Philadelphia | operating | - |
| AWS Salem Township Innovation Campus | Amazon Web Services | Salem Township | under construction | - |
| AWS Falls Township data center (Keystone Trade Center) | Amazon Web Services | Falls Township | planned | - |
| QTS Salem Township campus | QTS Data Centers | Salem Township | planned | - |
| Pennsylvania Digital I (PAX) Carlisle campus | Pennsylvania Data Center Partners / PowerHouse Data Centers | Carlisle | announced | - |
| York II Energy Center data center | Energy Capital Partners | Peach Bottom Township | announced | - |
| Shippingport Industrial Park data center (Project Phoenix) | Frontier Group of Companies / Aligned Data Centers | Shippingport Borough | planned | - |
| Sentinel East Whiteland data center (Green Fig) | Sentinel Data Centers | East Whiteland Township | under construction | - |